Studying Genes in Samples From Younger Patients With Adrenocortical Tumor

Children's Oncology Group

Status: Completed

Conditions: Adrenocortical Carcinoma

Treatments: Genetic: RNA analysis; Genetic: nucleic acid sequencing; Genetic: gene expression analysis; Genetic: polymorphism analysis; Genetic: DNA methylation analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01528956

COG-ARAR12B1 (Other Identifier)

ARAR12B1 (Other Identifier)

NCI-2012-00244 (Registry Identifier)

CDR0000724572 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies genes in samples from younger patients with adrenocortical tumor.

Full description

OBJECTIVES:

• To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs) analysis in pediatric adrenocortical tumors and compare those results to those of the same patient's normal cells.

OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep sequencing, micro RNA , methylation status, copy variation, and single-nucleotide polymorphisms. Results are then compared with patients' normal cells.

Enrollment: 10 estimated patients

Sex: All

Ages: Under 21 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Banked tumor and blood samples obtained from patients enrolled on COG-ARAR0332 in North America and Brazil

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified