Studying Genes in Samples From Younger Patients With Rhabdomyosarcoma

Children's Oncology Group

Status

Completed

Conditions

Sarcoma

Treatments

Genetic: nucleic acid sequencing

Other: laboratory biomarker analysis

Genetic: mutation analysis

Study type

Observational

Funder types

NETWORK

NIH

Identifiers

NCT01585376

COG-ARST12B3 (Other Identifier)

NCI-2012-00729 (Registry Identifier)

ARST12B3 (Other Identifier)

CDR0000732173 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and find biomarkers related to cancer. It may also help doctors find better ways to treat cancer.

PURPOSE: This research trial studies genes in samples from younger patients with rhabdomyosarcoma.

Full description

OBJECTIVES:

To obtain a larger cohort of rhabdomyosarcoma samples (alveolar and embryonal) to establish a more accurate estimate of the frequency of particular genetic lesions.
To provide the statistical power to establish an unambiguous connection between focal genetic lesions, histological subtype, and outcome for patients with rhabdomyosarcoma.

OUTLINE: DNA samples are analyzed in solid and liquid phase for exons of all genes mutated from previous discovery. DNA is then eluted and sequenced by illumina platform.

Enrollment

58 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS: