Studying Non-motor Symptoms in HSP

University Hospital Tuebingen

Status: Completed

Conditions: SPG4

Treatments: Diagnostic Test: Brief Pain Inventory (BPI); Diagnostic Test: EuroQol five dimensions questionaire (EQ-5D); Diagnostic Test: Becks Depression Inventory (BDI); Diagnostic Test: Restless-leg Questionaire (RLS diagnostic criteria); Diagnostic Test: Modified Fatigue Impact Scale (MFI)

Study type: Observational

Funder types: Other

Identifiers

NCT03204773

NMS in HSP

Details and patient eligibility

About

Comparing the non-motor symptoms of patients with hereditary spastic paraplegia (HSP) to healthy controls (spouses, relatives or other healthy controls) by using the a number of specific questionaires

Full description

https://lamapoll.de/NMS_in_HSP

Enrollment: 236 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Group 1: Patients with HSP (hereditary spastic paraplegia)
• Group 2: Healthy controls
• Age 18 to 70 years
• Written, informed consent

Exclusion criteria

• Lack of ability for a written, informed consent
• Presence of spastic gait disorder or other neurological condition (Group 2)

Trial design

236 participants in 2 patient groups

HSP patients

Description:

Patients with hereditary spastic paraplegia regardless of their genetic mutation

Treatment:

Diagnostic Test: Modified Fatigue Impact Scale (MFI)

Diagnostic Test: EuroQol five dimensions questionaire (EQ-5D)

Diagnostic Test: Becks Depression Inventory (BDI)

Diagnostic Test: Restless-leg Questionaire (RLS diagnostic criteria)

Diagnostic Test: Brief Pain Inventory (BPI)

Healthy controls

Description:

healthy controls (spouses, relatives, or other healthy controls)

Treatment:

Diagnostic Test: Modified Fatigue Impact Scale (MFI)

Diagnostic Test: EuroQol five dimensions questionaire (EQ-5D)

Diagnostic Test: Becks Depression Inventory (BDI)

Diagnostic Test: Restless-leg Questionaire (RLS diagnostic criteria)

Diagnostic Test: Brief Pain Inventory (BPI)