Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic Leukemia

Children's Oncology Group

Status: Completed

Conditions: Leukemia

Treatments: Genetic: proteomic profiling; Other: laboratory biomarker analysis; Genetic: RNA analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01626183

COG-AALL12B8 (Other Identifier)

AALL12B8

NCI-2012-01980 (Registry Identifier)

CDR0000735509 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer

PURPOSE: This laboratory study is looking into RNA in samples from younger patients with T-cell (T) acute lymphoblastic leukemia (ALL).

Full description

OBJECTIVES:

• Characterization of the transcriptomic landscape in diagnosis and relapse of T-cell acute lymphoblastic leukemia (ALL) and the direct comparison with corresponding physiological samples (human thymus).
• Perform high-throughput transcriptome ribonucleic acid (RNA) sequencing using matched diagnostic T-precursor pediatric ALL samples (peripheral blood or bone marrow).

OUTLINE: Archived peripheral blood and bone marrow samples are analyzed for long non-coding RNA (IncRNA) expression and sequencing.

Enrollment: 20 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Peripheral blood and bone marrow samples from pediatric patients with diagnosed and relapsed T-ALL

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified