Studying the Neuronal Basis of Human Social Cognition

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Mass General Brigham

Status

Enrolling

Conditions

Neurosciences

Treatments

Behavioral: Behavioral testing during neuronal recordings

Study type

Interventional

Funder types

Other

Identifiers

NCT05324579
2009P000218

Details and patient eligibility

About

This proposal aims to study the role that the dorsal prefrontal cortex plays in human social cognition.

Full description

Despite ongoing progress in the understanding of social behavior, little is known about the single-neuronal mechanisms that underlie human social cognition. The investigators will obtain single-neuronal recordings from the prefrontal cortex in participants undergoing clinically planned deep brain stimulation (DBS) electrode placement. The study population will consist of subjects undergoing planned DBS placement. Prospective participants will be selected for surgery irrespective of their participation in the study. After consenting to the study, the participants will be allowed to withdraw from participation at any time. No control subjects will be used. Instead, each subject will act as their own control based on task performance. For the study, neuronal recordings will be integrated within planned neurosurgical care and will be obtained from the prefrontal cortex as participants perform a brief behavioral task. During recordings and prior DBS placement, the participants are normally asked to make movements or answer questions based on verbal cues to aid in targeting the correct areas. The participants will be additionally asked to perform a brief linguistic-based task in which scenarios containing social agents are presented to the participants and in which they have to verbally describe/answer questions about them. Following cortical recordings and stimulation, the standard clinical procedure and DBS electrode placement proceeds as planned. The neuronal and behavioral data will then be analyzed off-line.

Enrollment

20 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. 18 years old or older
  2. patients able to give informed consent

Exclusion criteria

  1. Children under 18
  2. Significant co-morbidities
  3. Claustrophobia or general anxiety that may impact intraoperative testing
  4. Use of CNS-active medications including stimulants and antipsychotics which may alter
  5. Pregnancy
  6. Operative events that will require expedition of the surgery.
  7. Poor tolerance of testing by the patient
  8. Increased abnormal cortical excitability
  9. Necessity to administer drugs that will interfere with mapping

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

20 participants in 1 patient group

Neurosurgical subjects
Experimental group
Description:
Subjects undergoing intracranial neurosurgical procedures
Treatment:
Behavioral: Behavioral testing during neuronal recordings

Trial contacts and locations

2

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Central trial contact

Yoav Kfir, PhD; Ziv Williams, MD

Data sourced from clinicaltrials.gov

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