Studying Tumor Tissue Samples and Blood Samples to Learn More About DNA Changes in Patients With Lung Cancer

University of California (UC) Davis

Status: Enrolling

Conditions: Lung Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT00899405

UCD-155

225287

CDR0000583056 (Other Identifier)

UCD-200412410

Details and patient eligibility

About

RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This laboratory study is looking at tumor tissue samples and blood samples to learn more about DNA changes in patients with lung cancer.

Full description

OBJECTIVES:

• Examine the mutational status of the EGFR pathway in tumor and blood samples from patients with lung cancer.
• Correlate the EGFR pathway mutations in these samples with clinical outcomes of these patients.

OUTLINE: Archived tumor tissue and blood samples are analyzed via PCR to detect EGFR pathway mutations in DNA.

Enrollment: 800 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed lung cancer

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• May have received prior EGFR inhibitors

Trial design

800 participants in 1 patient group

Patients with lung cancer

Description:

Collection of archival tumor specimen at the beginning of the study and collection of blood samples at the beginning of the study and then at regular intervals