SU5416 and Paclitaxel in Treating Patients With Recurrent, Locally Advanced or Metastatic Cancer of the Head and Neck

Case Comprehensive Cancer Center (Case CCC)

Status and phase

Completed

Phase 1

Conditions

Head and Neck Cancer

Treatments

Drug: paclitaxel

Drug: semaxanib

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT00005647

U01CA062502 (U.S. NIH Grant/Contract)

P30CA043703 (U.S. NIH Grant/Contract)

NCI-T99-0084

CWRU1399

CWRU-1399

Details and patient eligibility

About

RATIONALE: SU5416 may stop the growth of head and neck cancer by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining SU5416 with chemotherapy may kill more cancer cells.

PURPOSE: Phase I trial to study the effectiveness of SU5416 and paclitaxel in treating patients who have recurrent, locally advanced, or metastatic cancer of the head and neck.

Full description

OBJECTIVES:

Determine the maximum tolerated dose and safety of SU5416 and paclitaxel in patients with recurrent or metastatic head and neck cancer.
Determine the antiangiogenesis effect of this combination regimen in these patients.
Determine the toxicity, pharmacodynamic effects, and pharmacokinetic parameters of this combination.

OUTLINE: This is a dose escalation study.

Patients receive paclitaxel IV over one hour on day 1 and SU5416 IV over one hour on days 1 and 4. Treatment continues weekly in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of paclitaxel and SU5416 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 6 patients experience dose limiting toxicities.

PROJECTED ACCRUAL: A total of 34 patients will be accrued for this study within 9-15 months.

Enrollment

12 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

Metastatic or loco-regionally recurrent malignancy of the head and neck (including salivary gland and thyroid) that is incurable by surgery or radiotherapy
At least two distinct tumor masses OR
One tumor mass at least 3 cm in diameter
No brain metastases
No pulmonary metastases as only site of disease

PATIENT CHARACTERISTICS:

Age:

18 and over

Performance status:

ECOG 0-2

Life expectancy:

At least 12 weeks

Hematopoietic:

WBC at least 3,500/mm3
Granulocyte count at least 1,500/mm3
Platelet count at least 100,000/mm3
Hemoglobin greater than 9.0 g/dL

Hepatic:

PT and PTT normal OR
INR ratio less than 1.1
Bilirubin less than 1.5 mg/dL
AST and ALT less than 2 times upper limit of normal

Renal:

Creatinine less than 1.5 mg/dL
Creatinine clearance greater than 60 mL/min

Cardiovascular:

No New York Heart Association class III or IV heart disease
No uncompensated coronary artery disease
No history of myocardial infarction or severe or unstable angina within the past 6 months
No severe peripheral vascular disease
No deep venous thrombosis or arterial thrombosis within the past 6 months
No known hypercoagulable syndrome with predisposition to venous or arterial clots

Pulmonary:

No pulmonary embolism within the past 6 months

Other:

No prior cerebral hemorrhage
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

Not specified

Chemotherapy:

At least 3 weeks since palliative chemotherapy (6 weeks for mitomycin or nitrosoureas) and recovered
At least 4 weeks since combined chemoradiotherapy and recovered
Must be recovered from prior taxanes

Endocrine therapy: