Sub-threshold Pacing to Prevent Pacemaker-induced Ventricular Tachycardia

Johannes Gutenberg University (JGU)

Status: Completed

Conditions: ICD Shock Therapy; Ventricular Tachyarrhythmias; ICD Shock Burden

Treatments: Other: Programming the pacemaker output for ventricular back-up pacing to a sub-threshold level

Study type: Observational

Funder types: Other

Identifiers

NCT01906775

PIT in ICD patients

Details and patient eligibility

About

Implantable cardioverter defibrillators (ICD) may have the capacity to provoke or worsen ventricular tachyarrhythmias (VT). It has been reported that ICD shocks by itself can increase mortality. This study aimed to determine the role of back-up pacing-induced VT (PIT) to the overall ICD shock burden by avoiding pause-related ventricular back-up pacing by programming the pacing output to a sub-threshold level for ineffective pacing.

Enrollment: 550 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age > 18 years
• implanted ICD
• occurrence of pacemaker-induced VT

Exclusion criteria

• documentation of pause-related syncope
• AV block
• sick-sinus syndrome
• younger than 18 years

Trial design

550 participants in 1 patient group

Patients with PIT

Description:

Identification of patients with pacemaker-induced ventricular tachycardias

Treatment:

Other: Programming the pacemaker output for ventricular back-up pacing to a sub-threshold level