Subacromial Injection of Allogeneic Platelet Rich Plasma (PRP) for Shoulder Impingement Syndrome

Seoul National University

Status

Completed

Conditions

Shoulder Impingement Syndrome

Treatments

Procedure: Allogeneic PRP injection into the subacromial space

Procedure: Steroid injection into the subacromial space

Study type

Interventional

Funder types

Other

Identifiers

NCT02019537

BRM-13-01

Details and patient eligibility

About

The purpose of this study is to investigate the efficacy of allogeneic PRP in patients with subacromial impingement disease

Enrollment

60 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male or female 18 years of age and older
Patients who have unilateral shoulder pain.
Patients who have had pain at least for 3 months
To be included in the study- participants are required to have a & b.(mentioned below)
1. Pain with one of the two tests
  - Neer's sign: passive overpressure at full shoulder flexion with the scapula fixed
  - Hawkins test: passive internal rotation at 90 degree of shoulder flexion in the scapular plane and in progressive degree of horizontal adduction
2. Pain with one of the two tests
  - Painful arc: active shoulder abduction
  - Jobe's test: The examiner passively elevates the patient's shoulder to 90 degrees of abduction with internal rotation. The examiner then applies a downward pressure against the arm

Exclusion criteria

Patients who received any drug by subacromial injection for treatment within 3 months prior to this enrollment.
Patients who have a history of shoulder trauma including dislocation- subluxation- and fracture- breast cancer- or surgery around shoulder- neck and upper back
Patients who have a isolated acromioclavicular joint pathology
Patients who have a full-thickness rotator cuff tear (evidenced by MR or ultrasonography)
Patients with symptomatic cervical spine disorders
Patients who have a History of allergic adverse reactions to corticosteroid
Patients are unable to give informed consent to participate in the study
Patients are unable to come into the clinic for regular follow-up
Patients with adhesive capsulitis- acromioclavicular arthropathy- polyarthritis- infectious arthritis- rheumatoid arthritis or diagnosed fibromyalgia
Patients with concurrent bilateral shoulder pain
Patients with neurological deficit
Patients who have severely abnormal radiological findings including malignancy, severe osteoarthritis of the glenohumeral joint, severe skeletal abnormalities decreasing the subacromial space and etc.
Presence of shoulder pain with limitation of both active and passive movements of the glenohumeral joint of 25% in at least 2 directions (abduction, flexion, external rotation, internal rotation), as compared with the contralateral shoulder or with normal values
Patients with Diabetes mellitus
Patients taking anticoagulants
Pregnant women or lactating mothers
Patients who are difficulty participating in data collection due to communication problem and serious mental illness
Patients with serious condition which can affect this study such as severe cardiovascular diseases- renal diseases- liver diseases- endocrine diseases- and cancers