Subclassification of the Syndrome of Inappropriate ADH Secretion

University of Wuerzburg

Status: Completed

Conditions: Hyponatremia

Study type: Observational

Funder types: Other

Identifiers

NCT01341665

5/08

Details and patient eligibility

About

The aim of this study is to evaluate the different types of osmotic dysregulation in patients with Syndrome of Inappropriate ADH (SIADH) and, hence, to analyze the pathophysiology of SIADH.

These types will be characterized by measurement of AVP and copeptin while performing an osmotic stimulation with infusion of hypertonic saline.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age > 18 years,
• hyponatremia < 132 mmol/L
• SIADH

Exclusion criteria

• age < 18 years
• cerebral metastases
• serum sodium > 132mmol/L