Subclinical Hypothyrodism and Ovarian Reserve

Assiut University

Status: Enrolling

Conditions: Fertility Disorders

Treatments: Behavioral: retrospective charts reviewing

Study type: Observational

Funder types: Other

Identifiers

NCT05409729

AMH

Details and patient eligibility

About

This study aimed to evaluate the potential association of subclinical hypothyrodism and ovarian reserve in reproductive age in age groups more than 35 and age groups less than 35 using retrospective study included women with subclinical hypothyrodism and controls .Evaluation of potential association of antithyroid antibodies positivity on ovarian reserve

Primary outcome:

Measure the association of SCH with ovarian reserve markers (basal FSH ,LH/basal AFC /AMH)

Full description

Thyroid dysfunction is one of the commonest disorders in women of reproductive age .there is association between subclinical hypothyrodism and infertility and ovarian reserve .It's known that subclinical hypothyrodism can be associated with reduced ovarian reserve in women more than 35 years old .Aclear association between subclinical hypothyrodism and ovarian reserve not established in reproductive age in women less than 35 .This retrospective study investigate serum thyroid hormone /Antithyroid hormone ,ovarian reserve markers (basal FSH,AMH,Antral follicle count on day 2-4/prolactin level .

Enrollment: 300 estimated patients

Sex: Female

Ages: 13 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All reproductive age groups included women less than 35 and women more than 35

Exclusion criteria

• Previous ovarian surgery Women with long term thyroid hormone replacement Endometriosis History of radiotheraby