Subclinical Organ Damage in Overweight and Obese Patients: Does Presence of Metabolic Syndrome Matter?

Goztepe Training and Research Hospital

Status: Unknown

Conditions: Obese; Overweight; Subclinical Organ Damage; Metabolic Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT01586754

34

Details and patient eligibility

About

Microalbuminuria and homocysteine levels are shown to be markers for endothelial dysfunction and subclinical organ damage and predictors of cardiovascular risk in several epidemiologic and randomized clinical trials. Carotis intima-media thickness is also found to be elevated in early stages of atherosclerosis. Recent studies have shown correlations between homocysteine, microalbumin levels and carotis intima-media thickness in type 2 diabetics but no data exists for obese or overweight patients who also have metabolic syndrome, in terms of markers of subclinical organ damage. Since obesity is a risk factor for cardiovascular disease and since it is known that patients with metabolic syndrome are at higher risk of cardiovascular events, the investigators wanted to examine whether there is an association between homocysteine, microalbumin levels and carotid intima-media thickness in patients with or without metabolic syndrome, who are either overweight or obese.

Enrollment: 100 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. 18-80 years
2. BMI >= 25
3. Ex or non-smokers (must have quit smoking at least 5 years ago)

Exclusion criteria

1. NIDDM or IDDDM
2. Nephropathy (GFR < 60 ml/min), previous history of coronary artery disease or peripheral arterial disease
3. Current smokers
4. Active infection or other acute illness

Trial design

100 participants in 2 patient groups

With Metabolic Syndrome

Without Metabolic Syndrome