Subconjunctival Injection of Allogeneic Mesenchymal Stem Cells in Severe Ocular Chemical Burn (SYMBOLpreclini)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Completed

Conditions: Bone Marrow Donor

Treatments: Other: bone marrow harvest

Study type: Observational

Funder types: NETWORK

Identifiers

NCT03967275

EGN_2018_11

Details and patient eligibility

About

The objective of this pre-clinical study is to demonstrate the robustness of Bone Marrow derived Mesenchymal Stem Cells (BM-MSC) production, to treat patients with severe eye burns.

For bone marrow donors who agree to participate, a 10 ml BM sample will be collected apart the 1 liter BM dedicated to transplantation.

A maximum of three donors of allogeneic BM-MSCs will be included. A ready-to-use BM-MSC suspension will be produced and stored for 10 years to accumulate data about stability of cryopreserved cells.

Enrollment: 7 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient with a bone marrow donation planned

Exclusion criteria

• The donor is finally not eligible
• The harvest cannot be performed
• The sample cannot be obtained during the BM harvest procedure