Subcutaneous Nitroglycerin for Pediatric Radial Artery Cannulation
Status
Conditions
Treatments
Details and patient eligibility
About
The primary objective of the study is to evaluate the vasodilative effect of subcutaneous nitroglycerin during ultrasound-guided radial artery cannulation in pediatric patients. The hypothesis of this study is that the subcutaneous nitroglycerin will increase the radial artery size and improve the first-attempt success rate of radial artery cannulation. This is a single-center, double-blind, randomized, placebo-controlled study comparing the effect of subcutaneous nitroglycerin and saline on radial artery cannulation in pediatric patients undergoing general anesthesia. Prior to the procedure, each patient will be randomized into either the control arm, saline, or study arm, nitroglycerin.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- General anesthesia
- Arterial cannulation for hemodynamic monitoring, multiple blood sample
Exclusion criteria
- Hypersensitivity or contraindication to nitroglycerine
- Unstable vital sign, significant arrhythmia or hypotension, Shock
- High risk of peripheral ischemia
- Skin disease, infection, hematoma, recent cannulation at radial artery.
- Increased intracranial pressure, Intracranial hemorrhage
- Glaucoma
- Recent use of PDE5 inhibitors (<24 hours after sildenafil or vardenafil; <48 hours after tadalafil)
Trial design
Primary purpose
Allocation
Interventional model
Masking
116 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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