Subjective Perception of Motor Control During Psychogenic Disorders (PERCMO-TNF)

Grenoble Alpes University Hospital Center (CHU)

Status: Terminated

Conditions: Somatoform Disorders

Treatments: Other: functional brain MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT02843932

38RC14.120*

Details and patient eligibility

About

The aim of this study is to reveal neurobiological bases of the motor control of conscious perception, thanks to new techniques of functional cerebral imaging (MRI), and potentials deteriorations connected to neuropsychiatric disorders like conversion disorder.

The Hospital University Center of Grenoble will provide patients from Neurology department, characterized with non psychogenic epileptic seizures and abnormal psychogenic movements, from conversive origin.

Subjects will be scanned by Magnetic Resonance Imaging during a motor paradigm inducing a perceptive conflict between two informations : proprioceptive information coming from the action (drawing) and visual information (draw's mark) that appears on the screen when there is movement.

Full description

New results will be provided about brain mechanisms involved in motor control perception among healthy patients and patients suffering from functional neurologic symptoms.

Enrollment: 14 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Signed informed consent
• Medical exam médical done before study participation
• Between 18 and 65 years
• Right-handed persons
• Conversion disorder based on DSM IV-R criterias
• Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking)

Exclusion criteria

• Subjects included in a clinical and/or therapeutic exeprimentation in progress
• People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia
• Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale
• History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding.
• Alcohol ingestion
• Pregnant, parturient or breastfeeding women
• All other categories of protected persons

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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14 participants in 1 patient group

Psychogenic disorders

Experimental group

Description:

Psychogenic movement disorders and seizures

Treatment:

Other: functional brain MRI