Subjective Sleep and Fatigue During and After Acute Diverticulitis

Herlev Hospital

Status: Completed

Conditions: Acute Diverticulitis

Study type: Observational

Funder types: Other

Identifiers

NCT01840904

CHU-3

Details and patient eligibility

About

The purpose of this study is to investigate subjective sleep quality and fatigue during and after Acute uncomplicated diverticulitis assessed by questionnaires and a sleep-diary. The investigators hypothesis is that subjective sleep and fatigue are correlated with the inflammatory activities.

Full description

An increasing number of experimental studies have showed that inflammation can induce disturbances in sleep architecture, mediated by cytokines. some studies showed that cytokines also induce daytime fatigue. In this study the investigators aim to describe the patient experiences of sleep and fatigue during the acute inflammation and the recovery, and the investigators seek to exam the correlation of fatigue with Polysomnography-measured night sleep and cytokine levels in plasma.

Following methods will be applied

• Other: Karolinska Sleepiness Scale
• Other: Physical Fatigue Scale
• Other: Visual Analog Scale and 10 point-scales to measure fatigue, general well-being, subjective sleep and pain
• Other: Sleep-diary
• Device: Polysomnograph - Embla Titanium (Natus Medical Incorporated, USA)
• Procedure: Plasma cytokines (IL-2, IL-6 and TNF-alfa(tumor necrosis factor))
• Procedure: Plasma CRP(C reactive protein) and leukocytes
• Device: Wrist-Actigraph - Octagonal Basic Motionlogger, Ambulatory monitoring Inc, New York, USA

Enrollment: 13 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CT-verified diverticulitis patients managed by antibiotic treatment at Herlev Hospital
• Pain and fever occurred less than 72 hours prior to the admission
• ASA (American Society of Anesthesiologists) score I to III

Exclusion criteria

• Surgical intervention needed
• Complicated diverticulitis
• Complications in relation to diverticulitis
• Pain and fever occurred more than 72 hours prior to the admission
• In anticoagulant treatment and heart rate control treatment
• Known Autoimmune disease
• Known medically treated sleep-disorder (insomnia, restless legs etc.) and sleep apnea
• Shift-work or jetlag
• Daily use of opioid, psychopharmaca, opioids or anxiolytics (including Hypnotics)
• Known psychiatry conditions in treatment with psychopharmaca
• Daily alcohol intake of more than 5 units or drug abuse
• Missing written consent
• Diabetes Mellitus
• Predicted bad compliance
• Pregnant or breast-feeding
• Urine or fecal incontinence
• Severe kidney disease
• Current cancer

Trial design

13 participants in 1 patient group

acute uncomplicated diverticulitis

Description:

CT-verified acute uncomplicated diverticulitis managed by antibiotics