Sublingual Administration of PPI

The Catholic University of Korea

Status: Unknown

Conditions: Gastric or Duodenal Ulcer

Study type: Observational

Funder types: Other

Identifiers

NCT01926600

24 hour pH

Details and patient eligibility

About

Compare 24-hour intragastric pH and therapeutic effectiveness of proton pump inhibitor (PPI) among different administration methods: per oral (PO), intravenous (IV), and sublingual (SL).

Full description

Intragastric pH and therapeutic effectiveness of PPI was compared among patients given PPI with different administration methods. 24 hour intragastric pH catheter was inserted in stomach of patients with peptic ulcer an hour prior to PPI administration in order to observe the initial change in pH. Three groups of patients were given PPI through per oral, intravenous, and sublingual administration methods. The hypothesis of this study is that sublingual administration will be faster than oral or IV administration in PPI dosing with respect to intragastric pH change and re-bleeding rate.

Enrollment: 60 estimated patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with peptic ulcer disease
• Age: 20-75 years old
• Patients who submitted informed consent

Exclusion criteria

• Peptic ulcer disease with spurting and oozing
• Shock, hypotension, pregnancy
• Gastrointestinal malignancy

Trial design

60 participants in 3 patient groups

PO

Description:

administrated by per oral

IV

Description:

Administrated by intravenous

SL

Description:

administrated by sublingual