Sublingual Versus Vaginal Misoprostol In Medical Treatment of First Trimestric Missed Miscarriage

Ain Shams University

Status and phase

Completed

Phase 3

Conditions

Missed Abortion

Treatments

Drug: vaginal misoprostol

Drug: sublingual misoprostol

Study type

Interventional

Funder types

Other

Identifiers

NCT02686840

ASUMH

Details and patient eligibility

About

The aim of this work is to compare the effectiveness of vaginal versus sub-lingual misoprostol for medical treatment of first trimester missed miscarriage.

Full description

In women with first trimetric-missed miscarriage, sublingual misoprostol may be as vaginal misoprostol in achievement of successful miscarriage so our aim was to compare the effectiveness of vaginal versus sub-lingual misoprostol for medical treatment of first trimester missed miscarriage.

Enrollment

200 patients

Sex

Female

Ages

18 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All women above 18 years of age
Less than 12 weeks of gestation.
Pregnancy is confirmed by pregnancy test or ultrasound scan.
missed abortion
Normal general and gynecological examination.
The size of the uterus on pelvic examination was compatible with the estimated duration of pregnancy

Exclusion criteria

Hemodynamically unstable.
Suspected sepsis with temperature 38 °C.
Concurrent medical illness e.g. hematological, cardiovascular, thromboembolism, respiratory illnesses, recent liver disease or pruritus of pregnancy.
Presence of intrauterine contraceptive device (IUCD).
Suspect or proven ectopic pregnancy.
Failed medical or surgical evacuation before presentation.
Known allergy to misoprostol.