Sublingual vs Vaginal Misoprostol for Termination of First Trimesteric Missed Abortion

Cairo University (CU)

Status and phase: Unknown; Early Phase 1

Conditions: Missed Abortion

Treatments: Drug: Misoprostol Pill

Study type: Interventional

Funder types: Other

Identifiers

NCT05001061

Misoprostol abortion

Details and patient eligibility

About

Efficacy of sublingual versus vaginal misoprostol in termination of first trimester missed abortion

Full description

study will be made on female patients with first trimester missed abortion confirmed by ultrasound . Participants will be divided into 2 groups one group (A) will receive sublingual Misoprostol and the other group(B) will receive vaginal Misoprostol as a 800 micro grams every 4 hours in both groups up to five doses the aim of the study is to compare efficay of sublingual and vaginal Misoprostol in complete termination of first trimester missed abortion and which route is the best will less side effects.

Enrollment: 288 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Women with an ultrasound diagnosis of missed abortion < 13 weeks gestation without any clinical criteria of Inevitable abortion.

Exclusion criteria

• Patients refused the medical treatment.
• Patients have contraindications of the drug (Misoprostol).
• Missed abortion associated with any signs of sepsis

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

288 participants in 2 patient groups

Sublingual Misoprostol for termination of first trimester missed abortion

Active Comparator group

Description:

Patients diagnosed as first trimester missed abortion will receive sublingual Misoprostol 800 micrograms every 4 hours up to five doses

Treatment:

Drug: Misoprostol Pill

Vaginal Misoprostol for termination of first trimester missed abortion

Active Comparator group

Description:

Patients diagnosed as first trimester missed abortion will receive vaginal Misoprostol 800 micrograms every 4 hours up to five doses

Treatment:

Drug: Misoprostol Pill