Substituting Mushrooms for Meat to Control Body Weight

Johns Hopkins Bloomberg School of Public Health

Status: Completed

Conditions: Obesity

Treatments: Behavioral: Weight-loss and weight-maintenance diets

Study type: Interventional

Funder types: Other

Identifiers

NCT01177085

Mush2

Details and patient eligibility

About

This is a one-year clinical trial to assess weight-loss, weight-maintenance, and biochemical parameters following a weight-control diet using either standard food guide pyramid alone, or standard food guide pyramid with substitution of mushrooms for meat.

Full description

This intervention study has a primary aim to assess omnivorous adult males and females' ability to control their weight over a period of 1 year. The control group will be required to use 90% lean ground beef a few times per week for one year while maintaining their personalized diet plans. The experimental group will have to follow their personalized diets as well, but will be required to substitute mushrooms for meat at least three times per week. Biochemical measures will also be assessed in response to the diet and weight loss.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male, female, >=18 years old
• Omnivorous
• BMI 25-40
• Seeking weight-loss

Exclusion criteria

• <18 years old
• Vegetarians
• Dislike mushroom
• Chronic disease
• HIV+
• Rheumatoid arthritis
• Pregnant or nursing child
• Must not self-report allergies to mushrooms

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

Mushroom

Experimental group

Description:

Mushroom enriched weight loss diet. Participants will be given a personalized diet plan, at a calorie level sufficiently restricted to result in a 20 lb weight loss over a period of 6 months, followed by a weight maintenance diet for a further 6 months.

Treatment:

Behavioral: Weight-loss and weight-maintenance diets

No mushroom diet

Active Comparator group

Description:

Participants will be given a personalized diet plan, without use of mushrooms as part of the diet, at a calorie level sufficiently restricted to result in a 20 lb weight loss over a period of 6 months, followed by a weight maintenance diet for a further 6 months.

Treatment:

Behavioral: Weight-loss and weight-maintenance diets