Substrate Metabolism During Exercise Following Ingestion of Ethanol

University of Bath

Status

Completed

Conditions

Exercise Metabolism Following Ethanol Ingestion

Treatments

Dietary Supplement: Ethanol

Study type

Interventional

Funder types

Other

Identifiers

NCT03404947

ETOH-hs565

Details and patient eligibility

About

This study will investigate how ethanol (pure alcohol) influences carbohydrate and fat metabolism during prolonged, moderate intensity exercise. Participants will perform two bouts of cycling exercise with or without prior ingestion of ethanol, in a randomised order, separated by one week.

Full description

Very little research has investigated the influence of ethanol on metabolism during prolonged exercise. Evidence suggests that delivery of fat to the working muscles during exercise may be limited with ethanol and therefore this may shift the relative proportions of energy derived from muscle stores of carbohydrate as a result (Jorfeldt & Juhlin-Dannfelt, 1976).

The current study aims to investigate how a small-moderate dose of ethanol influences where energy is derived from during a prolonged bout of moderate intensity cycling exercise.

Participants will visit the lab on three occasions, once for preliminary measurements of fitness and body composition, and twice for the experimental bouts of exercise. Body composition will be assessed using a dual-energy x-ray absorptiometry (DEXA) scan, which will measure lean mass, fat mass, and bone mineral density. Participants will then perform an incremental maximal oxygen uptake test to determine intensity for the experimental bouts of exercise.

The two experimental bouts of exercise include cycling on an exercise bike for 2 hours at 55% of their maximal oxygen uptake (i.e. fitness) following 1 hours rest. This will be performed under two conditions: with and without ethanol ingestion. Pre and post exercise muscle biopsies will be collected to assess muscle metabolism, with regular blood samples and expired breath samples being collected to further investigate fuel delivery and use by the working tissues. The experimental bouts of exercise will be performed 1 week apart in a randomised order.

Enrollment

8 patients

Sex

Male

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Habitual alcohol consumer (average 1-14 units per week)
BMI 18.5 - 29.9 kg/m2
Be able to attend the laboratory and willing to participate in necessary protocols
Be willing to undertake the durations of the exercise protocol (2 hours) ]
Have the capacity and willingness to provide informed consent (oral and written)

Exclusion criteria

Non-or excessive alcohol drinkers (0 or >14 units per week)
History of substance abuse
Habitual/previously habitual smokers
BMI >30.0 kg/m2
Experience contraindications to the administration of the proposed anaesthetic (Lidocaine Hydrochloride)