Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men

University of Toronto

Status: Completed

Conditions: Substrate Oxidation; Food Intake Regulation

Treatments: Other: Glucose Preload and Exercise Intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT01888991

CIHR MOP-111250 (Other Grant/Funding Number)

CIHR kids_26570

Details and patient eligibility

About

The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.

Full description

The relationship between substrate oxidation as measured by respiratory exchange ratio (RER) and food intake is undefined. This study is examining the effects of three modulators of substrate oxidation (RER), a glucose preload, exercise and age food intake regulation and net energy balance in normal-weight boys (9-12 y) and men (20-30 y).

Subjects (15 boys, 15 men) were measured in random order with treatments of beverages of either water or glucose followed by either moderate exercise or rest for 40 min. Measures included RER via indirect calorimetry, energy expenditure, subjective appetite, food intake measured at an ad libitum pizza meal and net energy balance as the sum of the calories of the glucose preload + calories from the pizza lunch minus energy expended at exercise or rest.

Enrollment: 30 patients

Sex: Male

Ages: 9 to 29 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Born at full term
• Men Age:20-29 years/BMI: 20-25
• Boys Age 9-11/BMI percentile: 15th to 85th:

Exclusion criteria

• Smokers
• Dieters
• Individuals with lactose intolerance, allergies to milk and dairy products
• Individuals with gastrointestinal problems
• Individuals with diabetes or other metabolic diseases
• Individuals scoring ≥ 11 on an Eating Habit Questionnaire

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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30 participants in 4 patient groups

water with resting condition

No Intervention group

glucose with resting condition

Experimental group

Treatment:

Other: Glucose Preload and Exercise Intervention

water with exercise condition

Experimental group

Treatment:

Other: Glucose Preload and Exercise Intervention

glucose with exercise condition

Experimental group

Treatment:

Other: Glucose Preload and Exercise Intervention