Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men

U

University of Toronto

Status

Completed

Conditions

Substrate Oxidation
Food Intake Regulation

Treatments

Other: Glucose Preload and Exercise Intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT01888991
CIHR MOP-111250 (Other Grant/Funding Number)
CIHR kids_26570

Details and patient eligibility

About

The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.

Full description

The relationship between substrate oxidation as measured by respiratory exchange ratio (RER) and food intake is undefined. This study is examining the effects of three modulators of substrate oxidation (RER), a glucose preload, exercise and age food intake regulation and net energy balance in normal-weight boys (9-12 y) and men (20-30 y). Subjects (15 boys, 15 men) were measured in random order with treatments of beverages of either water or glucose followed by either moderate exercise or rest for 40 min. Measures included RER via indirect calorimetry, energy expenditure, subjective appetite, food intake measured at an ad libitum pizza meal and net energy balance as the sum of the calories of the glucose preload + calories from the pizza lunch minus energy expended at exercise or rest.

Enrollment

30 patients

Sex

Male

Ages

9 to 29 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

* Born at full term * Men Age:20-29 years/BMI: 20-25 * Boys Age 9-11/BMI percentile: 15th to 85th:

Exclusion criteria

* Smokers * Dieters * Individuals with lactose intolerance, allergies to milk and dairy products * Individuals with gastrointestinal problems * Individuals with diabetes or other metabolic diseases * Individuals scoring ≥ 11 on an Eating Habit Questionnaire

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

30 participants in 4 patient groups

water with resting condition
No Intervention group
glucose with resting condition
Experimental group
Treatment:
Other: Glucose Preload and Exercise Intervention
water with exercise condition
Experimental group
Treatment:
Other: Glucose Preload and Exercise Intervention
glucose with exercise condition
Experimental group
Treatment:
Other: Glucose Preload and Exercise Intervention

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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