Subthalamic Nucleus Connectivity in Parkinson's Disease With Ultra-high Field Magnetic Resonance Imaging

Maastricht University Medical Centre (MUMC)

Status: Unknown

Conditions: Parkinson Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01981577

NL42613.068.13

Details and patient eligibility

About

The purpose of this study is to investigate the segregation of the subthalamic nucleus into its motor and non-motor regions in patients with Parkinson's disease and healthy controls with the aid of ultra-high field magnetic resonance imaging.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Both groups:

• Mental competence

Group 1:

• Parkinson's disease patients scheduled for deep brain stimulation surgery

Group 2:

• Age and gender matched volunteers

Exclusion criteria

Both groups:

• Head injury
• Stroke
• Other neurological diseases other than Parkinson's disease
• Metallic prostheses or pacemaker in the subject's body or other contra indications for MRI

Group 1:

• Inability to abstain from dopaminergic drug use

Group 2:

• Parkinson's disease
• Use of medication affecting the central nervous system

Trial design

20 participants in 2 patient groups

Patients with Parkinson's Disease

Healthy volunteers