Subthalamic Nucleus Stimulation Effect on Gait Symmetry and Freezing of Gait (STIMSYM)

Grenoble Alpes University Hospital Center (CHU)

Status: Terminated

Conditions: Parkinson Disease

Treatments: Procedure: Unilateral reduction of stimulation; Procedure: Chronic Subthalamic nucleus stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT02704195

2013-A01323-42

Details and patient eligibility

About

Impact of unilateral modulation of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease

Full description

Unilateral modulation of subthalamic stimulation and its impact on freezing of gait in Parkinson's disease will be studied.

In a cross-over, doubleblind, randomized study, a 30% reduction of stimulation intensity of the less impacted side will be compared with chronic treatment with regard to frequency and duration of freezing of gait episodes.

Enrollment: 12 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients affiliated to social security Patient with idiopathic parkinson's disease, with deep brain stimulation since at least one year Freezing of gait Able to give inform consent

Exclusion criteria

Patient under guardianship, legal guardianship Psychosis Severe depression Severe cognitive troubles (Mattis < 130) Other neurologic or medical pathology interfering with gait

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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12 participants in 2 patient groups

Chronic Subthalamic nucleus stimulation

Active Comparator group

Description:

This arm is the reference, with the best stimulation parameters

Treatment:

Procedure: Chronic Subthalamic nucleus stimulation

Unilateral reduction of stimulation

Experimental group

Description:

30% unilateral reduction of Subthalamic nucleus stimulation

Treatment:

Procedure: Unilateral reduction of stimulation