Subthalamic Nucleus (STN) Stimulation and Obsessive-Compulsive Disorder (OCD)

Marie-laure Welter

Status and phase: Completed; Phase 2; Phase 1

Conditions: Obsessive Compulsive Disorder

Treatments: Procedure: No stimulation; Procedure: deep brain stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT00169377

P030422

Details and patient eligibility

About

Obsessive-compulsive disorder is a disabling and frequent disorder. In some patients, the medical treatment is ineffective. The pathophysiology of this disease is still unknown. Some data suggest that basal ganglia dysfunction could participate in the occurrence of OCD. The aim of this study is to evaluate the efficacy of subthalamic nucleus high-frequency stimulation in patients with severe OCD.

Enrollment: 16 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Severe obsessive-compulsive disorder

Exclusion criteria

• Contraindication to magnetic resonance imaging (MRI)
• Severe cognitive or behavioral disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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16 participants in 2 patient groups

Group A

Active Comparator group

Description:

Deep brain stimulation on followed by off

Treatment:

Procedure: No stimulation

Procedure: deep brain stimulation

Group B

Sham Comparator group

Description:

No stimulation, deep brain stimulation off followed by on

Treatment:

Procedure: No stimulation

Procedure: deep brain stimulation