Success Rate Natural Cycles Versus Modified Natural Cycles in Frozen Embryos

Acibadem University

Status: Unknown

Conditions: Infertility, Female

Treatments: Other: modified natural cycle; Other: embryo transfer; Other: natural cycle

Study type: Observational

Funder types: Other

Identifiers

NCT03798886

ATADEK-2018/20

Details and patient eligibility

About

There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome. Now a days making frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer

Full description

There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome. Now a days making frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer, with reports from observational studies and randomized controlled trials suggesting that:

1. The endometrium in stimulated cycles is not optimal for implantation
2. Pregnancy rates are increased following FET
3. Perinatal outcomes are less affected after FET
4. Preimplantation genetic screening We will follow only natural and modified natural cycles patients. Spontaneous ovulation will documented with hormonal and sonographic monitoring. Hormonal monitoring are including estradiol and luteinizing hormone (LH). Sonographic monitoring is including follicule diameter (16-20 mm). At modified natural cycles we will use hCG triggering for ovulation approximately 16-20 mm diameter.

We will compare success rate between natural and modified natural cycles

Enrollment: 100 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient who are admitted to the IVF center and who will be transferred to frozen embryos.
• Infertile women under 40 years of age who accepted this study.
• Unexplained infertilite couple.
• All ovulatory patient.
• Male factor.
• Tubal factor.

Exclusion criteria

• Patients who made intrauterin surgery.
• Over 40 years of age women.
• Patients with preimplantation genetic diagnosis.
• Anovulatory patient.

Trial design

100 participants in 2 patient groups

Natural frozen embryo transfer group

Description:

In this group all embryos will be frozen when transfer planned sonographic follicle diameter measured. After spontaneous ovulation, embryo transfer will be planned. Luteal phase support will not be used.

Treatment:

Other: natural cycle

Other: embryo transfer

Other: modified natural cycle

modified natural embryo transfer group

Description:

In this group all embryos will be frozen when transfer planned sonographic follicle diameter measured. When follicle diameter is 16-17 mm we will apply hCG (recombinant hCG). After ovulation, embryo transfer will be done. Luteal phase support will not be used.

Treatment:

Other: natural cycle

Other: embryo transfer

Other: modified natural cycle