Successful Pregnancy and Delivery After AOA

Maria Fertility Hospital

Status: Completed

Conditions: Infertility

Treatments: Other: Strontium chloride (SrCl2); Other: Calcium ionophore

Study type: Interventional

Funder types: Other

Identifiers

NCT01595815

GJHS120509DK

Details and patient eligibility

About

Artificial oocyte activation with strontium chloride or calcium ionophore improves fertilization, embryo quality, pregnancy and delivery rate in women who showed complete fertilization failure or low fertilization rates

Enrollment: 100 patients

Sex: Female

Ages: 20 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Fertilization rate was less than 30% after conventional ICSI.
• Fertilization rate was less than 50% after ICSI with calcium ionophore.
• Repeated complete fertilization failure or low fertilization rates following ICSI in previous cycles

Exclusion criteria

• Fertilization rate was more than 30% after conventional ICSI
• Fertilization rate was more than 50% after ICSI with calcium ionophore.
• Successful pregnancy and delivery after ICSI in previous cycles

Trial design

100 participants in 2 patient groups

Conventional ICSI

Active Comparator group

Description:

The couple showed complete fertilization failure after ICSI.

Treatment:

Other: Calcium ionophore

Other: Strontium chloride (SrCl2)

Convention ICSI

Active Comparator group

Description:

The couple showed a low fertilization rates after ICSI.

Treatment:

Other: Calcium ionophore

Other: Strontium chloride (SrCl2)