Successive Doses of GnRH Agonist Versus Single Dose of GnRH Agonist to Trigger Ovulation in Hyper-responders

Bedaya Hospital

Status and phase: Not yet enrolling; Phase 2

Conditions: Infertility

Treatments: Drug: Successive doses GnRH agonist; Drug: Single dose GnRH agonist

Study type: Interventional

Funder types: Other

Identifiers

NCT07569315

Successive/Single GnRH agonist

Details and patient eligibility

About

The aim of this randomized controlled study is to compare the efficacy of three successive doses of a GnRH agonist ( administered 36 , 24 and 12 hours before oocyte retrieval ) with a single dose of a GnRH agonist ( administered 36 hours before oocyte retrieval ) in triggering ovulation in hyper-responders

Enrollment: 190 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• GnRH antagonist IVF cycle
• Hyper-responders to induction of ovulation

Exclusion criteria

• Hypogonadotrophic hypogonadism
• Endometriosis
• History of recurrent abortion

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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190 participants in 2 patient groups

Successive doses GnRH agonist

Experimental group

Description:

Three successive doses of GnRH agonist are administered 36 , 24 and 12 hours before oocyte retrieval

Treatment:

Drug: Successive doses GnRH agonist

Single dose GnRH agonist

Active Comparator group

Description:

A single dose of GnRH agonist is administered 36 hours before oocyte retrieval

Treatment:

Drug: Single dose GnRH agonist