Succinylcholine vs Rocuronium for Prehospital Emergency Intubation (CURASMUR)

Centre Hospitalier Universitaire de la Réunion

Status and phase: Completed; Phase 3

Conditions: Shock; Major Trauma; Coma; Respiratory Distress

Treatments: Drug: Succinylcholine : 1mg/kg; Drug: Rocuronium : 1.2 mg/kg

Study type: Interventional

Funder types: Other

Identifiers

NCT02000674

2013/CHU/05

2013-001438-16 (EudraCT Number)

Details and patient eligibility

About

All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included in order to compare the use of succinylcholine vs Rocuronium for prehospital emergency intubation.

Full description

All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included. All intubation will be performed by an emergency physician or a nurse specialized in anesthesia. For patients with spontaneous cardiac activity, rapid sequence intubation will be performed to allow intubation.

Comparisons studied will be : Intubation success rate at the first laryngoscopy, glottis exposure assessed by Cormack and Lehane classification, difficult intubation rate assessed by the Intubation Difficult Score (IDS), the conditions of intubation assessed by the Copenhagen score, the need for alternative airway techniques and the immediate post intubation complications rate as vomiting, dental trauma, pulmonary inhalation, arterial desaturation , hypotension episodes and cardiac arrest occurrence.

Enrollment: 1,321 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context

Exclusion criteria

• Patients in cardiac arrest;
• Patients under-18s;
• Patients under guardianship ;
• Pregnancy known;
• Patients with cons to one of the following three drugs: rocuronium, succinylcholine, sugammadex;
• Patients not affiliated to a social security scheme (beneficiary or legal).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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1,321 participants in 2 patient groups

Administration of Succinylcholine

Active Comparator group

Description:

Intubation after IV administration of Succinylcholine 1mg/kg

Treatment:

Drug: Succinylcholine : 1mg/kg

Administration of Rocuronium

Experimental group

Description:

Intubation after IV administration of Rocuronium 1.2 mg/kg

Treatment:

Drug: Rocuronium : 1.2 mg/kg