Sudden Death Stratification

Civil Hospices of Lyon

Status: Completed

Conditions: Non-ischemic Cardiomyopathy

Treatments: Diagnostic Test: Cardiac MRI

Study type: Observational

Funder types: Other

Identifiers

NCT04607265

69HCL20_0838

Details and patient eligibility

About

Sudden cardiac death (SCD) risk stratification is a challenge in non-ischemic cardiomyopathy (NICM). The underlying mechanism of monomorphic ventricular tachycardia (VT) is mostly scar related. While electrophysiological mechanisms underlying ventricular arrhythmia are well known, late gadolinium enhanced (LGE) cardiac MRI-3D reconstructions are now able to guide VT ablation procedures. Such exam may help in identifying specific properties of scar at risk of malignant arrhythmia.

Enrollment: 30 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult with NICM
• Previous history of ventricular tachycardia (VT) and no previous history of VT

Exclusion criteria

• Inherited cardiomyopathies
• Previous history of myocarditis WITHOUT oedema/scar at the MRI

Trial design

30 participants in 2 patient groups

Ventricular tachycardia (VT) group

Description:

NICM patients admitted for a VT ablation with a pre-operative cardiac- MRI.

Treatment:

Diagnostic Test: Cardiac MRI

Control group

Description:

NICM patients without ventricular arrhythmia and a previous cardiac-MRI. The matching with the VT group was based on the age of the patients, the mean LVEF, the time between the initial diagnosis and the MRI examination, and the origin of the NICM.

Treatment:

Diagnostic Test: Cardiac MRI