Sugammadex Provide Better Surgical Condition Compared With Neostigmine in Laryngeal Microsurgery.

Seoul National University

Status: Completed

Conditions: Neuromuscular Blockade

Treatments: Other: Injection of neostigmine or sugammadex

Study type: Interventional

Funder types: Other

Identifiers

NCT02330172

B1312230009

Details and patient eligibility

About

This study aims to make a comparison of surgical condition and recovery time between rocuronium 0.45 mg/kg and neostigmine group and rocuronium 0.9 mg/kg and sugammadex group.

Full description

This study aims to make a comparison of surgical condition and recovery time between moderate neuromuscular bloackade with reversal using neostigmine group and deep neuromuscular bloackade with reversal using sugammadex group.

Enrollment: 44 patients

Sex: All

Ages: 19 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologist Physical status classification 1 or 2 elective laryngeal microsurgery under general anesthesia

Exclusion criteria

• BMI >25 or < 20 kg/m2 Patients taking intercurrent medication Glutamic Oxalacetate Transaminase or Glutamic Pyruvate Transaminase > 40 IU/L, Cr > 1.4 mg/dl

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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44 participants in 2 patient groups

rocuronium 0.45 - neostigmine

Active Comparator group

Description:

when anesthetic induction, inrocuronium 0.45 mg/kg will be administered for muscle relaxation. When the end of operation, a injection of neostigmine or sugammadex will be administered.

Treatment:

Other: Injection of neostigmine or sugammadex

rocuronium 0.9 - sugammadex

Active Comparator group

Description:

When anesthetic induction, rocuronium 0.9 mg/kg will be injected to rocuronium 0.9 - sugammadex group for muscle relaxation. When the end of operation,, a injection of neostigmine or sugammadex be administered.

Treatment:

Other: Injection of neostigmine or sugammadex