Sugammadex Reversal of Neuromuscular Blockade and Postoperative Bleeding (Suga_bleeding)

Mansoura University

Status: Unknown

Conditions: Blood Coagulation Tests ( INR, APTT)

Treatments: Drug: Intravenous neostigmine and atropine; Drug: Sugammadex intravenous

Study type: Interventional

Funder types: Other

Identifiers

NCT02939430

Refa-suga-bleeding

Details and patient eligibility

About

Sugammadex is new drug that is used for reversal of rocuronium induced muscle relaxation. benefits of reversal of neuromuscular blockade appears to be of great value in living donor liver transplant recipients. However, Few Clinical reports have investigated the anticoagulant effect of sugammadex. In this study, effects of sugammadex on bleeding profile of living donor liver transplantation will be investigated.

Enrollment: 40 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all candidates for living donor liver transplantation

Exclusion criteria

• massive intraoperative bleeding manifestations of early graft dysfunction

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Control

Active Comparator group

Description:

Reversal of neuromuscular blockade will be performed using classic drugs (neostigmine 80 mic/kg and atropine 40 mic/kg)

Treatment:

Drug: Intravenous neostigmine and atropine

Sugammadex group

Experimental group

Description:

Reversal of neuromuscular blockade will be performed using Sugammadex 2mg/kg

Treatment:

Drug: Sugammadex intravenous