Sugar-replacement Sweeteners, and Blood Sugar Control (SIR)

The Washington University

Status: Completed

Conditions: Obesity

Treatments: Other: Water; Other: Sucralose

Study type: Interventional

Funder types: Other

Identifiers

NCT01128829

09-0583/ 201102383

Details and patient eligibility

About

Several sugar-replacement sweeteners are currently on the market, including saccharine (ex. Sweet'N Low), aspartame (ex. Equal), and sucralose (ex. Splenda). The purpose of this study is to examine wether non caloric sweeteners affects how well the body works to control blood sugar. The study includes detailed blood sugar testing after drinking liquids that may contain sucralose. The investigators hypothesize that drinking liquids with sucralose will effect the amounts of specific appetite-affecting substances naturally produced by the body.

Enrollment: 17 patients

Sex: All

Ages: 21 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• body mass index (BMI) over 30.
• Homeostasis model assessment of insulin resistance (HOMA-IR) < or = 2.6

Exclusion criteria

• smoking or smoked within last six months
• pregnant or breastfeeding
• have malabsorptive syndromes
• intestinal inflammatory disease
• diabetes
• liver or kidney disease
• fructose intolerance
• consuming more than one can of diet beverage or one spoonful of non-nutritive sweeteners (e.g. sucralose, aspartame, or saccharine) a week.
• taking any medication that might affect metabolism or taste.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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17 participants in 2 patient groups

water-sucralose

Experimental group

Description:

Subjects in this group drank "water" 10 min before drinking a glucose load on their first oral glucose tolerance test (OGTT) and drank "sucralose" 10 min before drinking a glucose load on their second OGTT. The two OGTT were separated on average by 1 week (i.e. washout was approximately 1 week).

Treatment:

Other: Sucralose

Other: Water

sucralose-water

Experimental group

Description:

Subjects in this group drank "sucralose" 10 min before drinking a glucose load on their first OGTT and drank "water" 10 min before drinking a glucose load on their second OGTT. The two OGTT were separated on average by 1 week (i.e. washout was approximately 1 week).

Treatment:

Other: Sucralose

Other: Water