Sugar Sweetened Beverages (SSB)- Effects on Metabolism

University of Zurich (UZH)

Status: Completed

Conditions: Metabolism

Treatments: Procedure: Soft drink consumption

Study type: Interventional

Funder types: Other

Identifiers

NCT01733563

SSB-Effects on metabolism

Details and patient eligibility

About

The objective of this study is to investigate the impact of sugar sweetened beverages on the fat metabolism of healthy young men. It is well known that consumption of beverages sweetened with fructose is associated with different health risks such as type 2 diabetes. The present study has been designed to dissect differences in the metabolic pathways of fructose and glucose, but also metabolic adaptations during fructose, glucose and sucrose diets. During a period of seven weeks subjects will consume either fructose, glucose or sucrose sweetened beverages or continue their usual drinking habits. During these seven weeks there will be different metabolic investigations using stable isotope tracers. First, the rate of lipolysis and beta-oxidation will be determined. Second, the rates of fatty acid synthesis will be measured. During all examinations there will also be substrate- and energy-utilization measurements by indirect calorimetry, blood analysis and morphometric measurements. Based on the literature main hypotheses are: Fructose enhances de novo lipogenesis postprandially and also in the fasting state significantly more than glucose by enhanced expression of lipogenic enzymes. Fructose decreases beta oxidation via downregulation of oxidative enzymes.

Enrollment: 96 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Healthy male volunteers aged 18-30
• BMI between 19-24 kg/m2
• Non-smoker

Exclusion criteria

• Acute or chronic infections, malignant disease, renal, hepatic (more than two-fold increased transaminases), pulmonary, neurological (epilepsy) or psychiatric diseases, manifested atherosclerosis, or any other disease precluding participation in the study.
• Diabetes
• Known alcohol, substance or drug abuse, concomitant medication
• More than three hours of physical exercise per week
• Consumption of more than 2 times 3 dl SSB daily
• Subjects likely to fail to comply with the study protocol
• Subjects who do not give informed consent

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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96 participants in 4 patient groups

fructose sweetened beverage

Experimental group

Description:

Soft drink consumption: Subjects have to drink a fructose sweetened beverage (3x 200ml per day, 13.3g fructose/100ml) during 7 weeks

Treatment:

Procedure: Soft drink consumption

glucose sweetened beverage

Experimental group

Description:

Soft drink consumption: Subjects have to drink a glucose sweetened beverage (3x 200ml per day, 13.3g glucose/100ml) during 7 weeks

Treatment:

Procedure: Soft drink consumption

sucrose sweetened beverage

Experimental group

Description:

Soft drink consumption: Subjects have to drink a sucrose sweetened beverage (3x 200ml per day, 13.3g sucrose/100ml) during 7 weeks

Treatment:

Procedure: Soft drink consumption

No change of eating habits

Experimental group

Description:

No Soft drink consumption (no soft drink diet): Subjects do not change their eating habits during 7 weeks

Treatment:

Procedure: Soft drink consumption