Suitability of DCE-MRI for Detection of Vascular Changes After VBT

Abramson Cancer Center at Penn Medicine

Status: Completed

Conditions: Carcinoma of the Cervix, Carcinoma or Carcinosarcoma of the Uterus

Treatments: Radiation: Radiotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01991808

UPCC 26812

Details and patient eligibility

About

This is a pilot study of DCE MR imaging to detect vascular changes in the vagina during and after radiotherapy n patients receiving adjuvant brachytherapyfor cervical or endometrial cancer.

Enrollment: 16 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Must be 18 years of age.
• Must have histologically confirmed carcinoma of the cervix, carcinoma or carcinosarcoma of the uterus.
• Subjects are receiving intracavitary brachytherapy.
• ECOG performance status of 0-2.
• Creatinine clearance 30.

Exclusion criteria

• Subjects with an inability to tolerate MR imaging (i.e. claustrphobia)
• Study subjects who have contraindication to MRI scanning such as but not limited to subjects with pacemakers, metal fragments in the eye or certain metallic implants.
• Patients who do not speak or read English.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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16 participants in 1 patient group

DCE-MRI

Experimental group

Treatment:

Radiation: Radiotherapy