Superficial Cervical Plexus Block Versus Ketamine in the Prevention of Chronic Pain After Thyroidectomy (Thyrobloket)

University Tunis El Manar

Status and phase: Completed; Phase 4

Conditions: Chronic Pain; Thyroidectomy

Treatments: Procedure: Superficial cervical plexus block; Drug: Ketamine perfusion

Study type: Interventional

Funder types: Other

Identifiers

NCT07230392

Thyrobloket

Details and patient eligibility

About

The goal of our work is to to compare the effect of preemptive Ketamine administration versus superficial cervical plexus block on the incidence of postoperative neuropathic pain in patients undergoing thyroidectomy

Enrollment: 69 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged 18 to 80 years
• Scheduled for thyroidectomy under general anesthesia.
• American Society of Anesthesiologists (ASA) physical status I-III.
• Able to understand the study procedures and provide written informed consent

Exclusion criteria

• Known allergy to ketamine or local anesthetics
• Severe renal impairment with estimated Glomerular Filtration Rate (eGFR) under 30 mL/min
• History of neurological disorders
• History of psychiatric illness
• History of severe cardiac disease (NYHA III-IV) or serious arrhythmias
• Pregnancy or breastfeeding
• Morbid obesity (BMI > 40 kg/m²)
• Cognitive or communication impairment
• Refusal to participate

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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69 participants in 2 patient groups

BCS Group

Active Comparator group

Description:

Patients received a bilateral ultrasound-guided superficial cervical plexus block after induction (Ropivacaine 0.2%,with a volume of 10 mL administered to each side)

Treatment:

Procedure: Superficial cervical plexus block

KETA group

Active Comparator group

Description:

Patients received intravenous ketamine (0.25 mg/kg bolus followed by a 2 µg/kg/min infusion).

Treatment:

Drug: Ketamine perfusion