Supernormal Oxygen Delivery for Patients With Severe Burns

Guangzhou Red Cross Hospital

Status and phase: Unknown; Early Phase 1

Conditions: Burn Surgery; Dobutamine

Treatments: Drug: Dobutamine

Study type: Interventional

Funder types: Other

Identifiers

NCT05241912

2022-005-01

Details and patient eligibility

About

This is a randomized double-blinded study to investigate in which the groups are designated as the control group and the goal-directed fluid therapy group to further evaluate significant differences in rate of complications during burn surgery.

Full description

This is a randomized double-blinded study to investigate the effect of control group and the goal-directed fluid therapy group on complications during surgery of the burn patients. The groups are designated as the control group and the oal-directed fluid therapy group to further evaluate significant differences in complications during the surgery.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Severe burn patients

Exclusion criteria

• Patients or families refuse to sign consent

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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100 participants in 2 patient groups

Control group

No Intervention group

Description:

Intraoperative fluid management: administration of 6-10 ml/kg/hr of crystalloid solution.

Goal-directed fluid group

Experimental group

Description:

Intervention: administration of dobutamine 0.01 - 0.04 U/min after induction of anesthesia. Intraoperative fluid management: administration of 2-4 ml/kg/hr of crystalloid solution.

Treatment:

Drug: Dobutamine