Supplemental Hydrogen Plus PQQ for Mitochondrial Biomarkers and Brain Function in Elderly With Mild Cognitive Impairment (CALERIE)

University of Novi Sad, Faculty of Sport and Physical Education

Status: Completed

Conditions: Age-associated Memory Impairment

Treatments: Dietary Supplement: Supplement; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT05910047

A13-CH-2023

Details and patient eligibility

About

The goal of this randomized controlled double-blind parallel-group interventional trial is to evaluate the effects of dietary supplementation with molecular hydrogen and pyrroloquinoline quinone in elderly. The main questions it aims to answer are: (1) whether the supplementation affects biomarkers of mitochondrial function in serum, and (2) whether the supplementation affects cognition and brain metabolism. The participants will be subjected to take the dietary supplement during 6 weeks.

Enrollment: 34 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 65 years
• MMSE scores ranged from 23-27
• Informed consent signed

Exclusion criteria

• Take part in exercise on a regular basis
• Severe chronic disease and acute injuries
• History of dietary supplement use during the past 4weeks
• No consent to randomization
• Participation in other studies

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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34 participants in 2 patient groups, including a placebo group

Supplement

Experimental group

Description:

One tablet of supplement before breakfast and dinner

Treatment:

Dietary Supplement: Supplement

Placebo

Placebo Comparator group

Description:

One tablet of inert compound before breakfast and dinner

Treatment:

Dietary Supplement: Placebo