Supplementation of Dual Probiotic Strains Reduced Fasting Triglyceride and Enhanced Apolipoprotein A-V Levels

Yonsei University

Status and phase: Completed; Phase 3

Conditions: Hypertriglyceridemia

Treatments: Dietary Supplement: placebo; Dietary Supplement: dual probiotics

Study type: Interventional

Funder types: Other

Identifiers

NCT02215694

probiotics_140801

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of dual probiotic strains containing Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on triglyceride and apolipoprotein A-V.

Full description

A randomized, double-blind, placebo-controlled study was conducted on 128 nondiabetic and hypertriglyceridemic (Plasma Triglyceride, 150-500 mg/dL) subjects. Over a 12 week test period, the probiotic group consumed 2g of powder daily containing dual probiotic strains, while the placebo group consumed the same without probiotics.

Enrollment: 128 patients

Sex: All

Ages: 24 to 68 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• nondiabetic (plasma fasting glucose, <126mg/dL; 2-hour plasma glucose, <200mg/dL)
• borderline to moderate hypertriglyceridemia (plasma triglyceride, 150-500 mg/dL)

Exclusion criteria

• lipid-lowering medications use
• any medications or supplement use
• any probiotics products use for the past 1 months
• dyslipidemia
• diabetes mellitus
• hypertension
• liver disease
• renal disease
• cardiovascular disease
• cerebrovascular disease
• pancreatitis
• cancer
• medication or alcohol abuse
• pregnant or breast feeding

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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128 participants in 2 patient groups, including a placebo group

probiotic group

Experimental group

Description:

consumed 2g of powder daily containing dual probiotics(Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032)

Treatment:

Dietary Supplement: dual probiotics

placebo group

Placebo Comparator group

Description:

consumed 2g of powder daily without probiotics

Treatment:

Dietary Supplement: placebo