Supplementation With Vitamin D, Calcium or Both on Calcium Absorption and Bone Mineral Content in Children With JRA

University of Missouri (MU)

Status and phase: Completed; Phase 3

Conditions: Juvenile Rheumatoid Arthritis

Treatments: Dietary Supplement: Calcium and cholecalciferol; Dietary Supplement: Cholecalciferol; Drug: Placebo; Dietary Supplement: Calcium

Study type: Interventional

Funder types: Other

Identifiers

NCT00570934

5387

Details and patient eligibility

About

2000 international units (IU) vitamin D, 1 gram (gm) calcium, or both given to children with Juvenile Rheumatoid Arthritis (JRA) may increase percent true calcium absorption, bone mineral turnover and/or bone mineralization.

Full description

Supplementation With 2000 IU Vitamin D, 1 gm Calcium or Both on Calcium Absorption and Bone Mineralization in Children With Juvenile Rheumatoid Arthritis may increase percent true calcium absorption, bone mineral turnover and/or bone mineralization.

Enrollment: 24 patients

Sex: All

Ages: 3 to 15 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Juvenile Rheumatoid arthritis

Exclusion criteria

• Steroid use

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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24 participants in 4 patient groups

Placebo

Experimental group

Description:

order of interventions placebo,calcium, cholecalciferol, calcium plus cholecalciferol

Treatment:

Dietary Supplement: Cholecalciferol

Dietary Supplement: Calcium and cholecalciferol

Drug: Placebo

Dietary Supplement: Calcium

Calcium

Experimental group

Description:

order of treatment calcium, placebo, calcium plus cholecalciferol, cholecalciferol

Treatment:

Dietary Supplement: Cholecalciferol

Dietary Supplement: Calcium and cholecalciferol

Drug: Placebo

Dietary Supplement: Calcium

Cholecalciferol

Experimental group

Description:

order of treatments cholecalciferol, calcium and Cholecalciferol, placebo, and calcium

Treatment:

Dietary Supplement: Cholecalciferol

Dietary Supplement: Calcium and cholecalciferol

Drug: Placebo

Dietary Supplement: Calcium

Calcium and cholecalciferol

Experimental group

Description:

order of treatment calcium and cholecalciferol, cholecalciferol, calcium, placebo

Treatment:

Dietary Supplement: Cholecalciferol

Dietary Supplement: Calcium and cholecalciferol

Drug: Placebo

Dietary Supplement: Calcium