Suprachoroidal Triamcinolone in Macular Edema for Patients With Non-Infectious Uveitis Resistant to Subtenon Triamcinolon

Baghdad college of medicine

Status and phase: Enrolling; Early Phase 1

Conditions: Non Infectious Uveitis; Macular Edema (ME)

Treatments: Drug: Suprachoroidal triamcinolone acetonide injection

Study type: Interventional

Funder types: Other

Identifiers

NCT07145008

2024-234

Details and patient eligibility

About

The goal of this study is to learn if a suprachoroidal triamcinolone injection can treat vision-threatening swelling in the center of the retina (macular edema) caused by non-infectious uveitis, especially in people who did not improve after a standard steroid injection around the eye (sub-Tenon injection).

The main questions it aims to answer are:

Does vision improve on the eye chart after the injection?

Does the injection lower retinal swelling (reduction in thickness) within 3 months?

Participants will:

Have a pre-treatment check (vision test, slit-lamp exam, and a retinal scan called OCT).

Receive one suprachoroidal triamcinolone injection under anesthetics drops in a sterile setting (operating room) with standard monitoring.

Return for visits about 1 month and 3 months after treatment for repeat vision tests, and OCT scans.

Contact the clinic if they notice pain, redness, new floaters, or worsening vision.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Non-infectious uveitis complicated with macular edema
• Uveitic macular edema of less than four months' duration
• Macular edema persisted despite lack of intra-ocular inflammation
• No response to posterior sub-Tenon triamcinolone acetonide injections

Exclusion criteria

• Those with epiretinal membrane-associated macular edema
• Below 18 years

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Suprachoroidal Triamcinolone treatment arm

Experimental group

Treatment:

Drug: Suprachoroidal triamcinolone acetonide injection