Surface Ablation With Corneal Cross Linking in Mild Keratoconus

Shahid Beheshti University

Status: Unknown

Conditions: Keratoconus; Corneal Cross-Linking

Treatments: Procedure: Photorefractive Keratectomy with Corneal Cross-Linking

Study type: Interventional

Funder types: Other

Identifiers

NCT05176171

SBMU

Details and patient eligibility

About

Interventional and comparative prospective study: Sixty-nine eyes (38 patients) suffering from keratoconus (stages 1-2 Amsler-Krumeich classification) will be divided into four groups. The four groups underwent topography- and non-topography-guided PRK with sequential and simultaneous CXL. The main outcome measures will be pre-and postoperative uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (CDVA), manifest refraction, contrast sensitivity, and keratometry

Enrollment: 50 patients

Sex: All

Ages: 30 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria for the study focused on patients over 34 (range from 34 to 41) with stable corneal topography and refraction for at least six months and an estimated residual bed thickness of >410 µm.

exclusion from the study included the presence of macular or retinal disease, dry eye, history of recurrent corneal erosions, anterior segment abnormalities, unstable refractive error, post-surgically residual stromal bed thickness of under 350 mm, autoimmune disease, collagen vascular disease, immunosuppressive therapy, or current use of systemic corticosteroids, diabetes mellitus, pregnancy, and lactation.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

Photorefractive Keratectomy with Corneal Cross-Linking

Experimental group

Description:

For correction of refractive error

Treatment:

Procedure: Photorefractive Keratectomy with Corneal Cross-Linking