Surface Mechanomyography Using a Parasternal Patch to Measure and Detect Respiratory Drive and Effort (PATCH-MMG)

University Hospital, Angers

Status: Completed

Conditions: Acute Respiratory Failure

Treatments: Device: non-invasive ventilation with or without resistance

Study type: Interventional

Funder types: Other

Identifiers

NCT06046898

49RC22_0395

Details and patient eligibility

About

Surface mechanomyography (sMMG) has been proposed as a tool to study muscle mechanical activity. sMMG is a noninvasive technique using specific transducers to record muscle surface oscillations due to mechanical activity of the motor units . It could be of major interest for the detection of respiratory efforts in patients with respiratory failure. This study aims at assessing the performances of sMMG to measure and detect respiratory drive and effort in healthy volunteers.

Enrollment: 10 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy volunteer
• Age > 18 and < 60
• Informed consent
• Fasting
• Subjects covered by or having the rights to medical care assurance

Exclusion criteria

• Obesity (BMI > 30 kg.m-2)
• Respiratory disease
• Cardiovascular disease
• Contraindication to the insertion of a nasogastric tube
• Incapacity to consent
• Pregnancy, breastfeeding
• Bad understanding of the French language,
• Other protected person according to articles L1121.7 and L1121.8 of the French Public Health Act.

Trial design

Primary purpose: Device Feasibility

Allocation: N/A

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 6 patient groups

SV - R / SV + R / PSV

Experimental group

Description:

Spontaneous ventilation without resistance (SV - R) / Spontaneous ventilation with resistance (SV + R) / Pressure support ventilation (PSV)

Treatment:

Device: non-invasive ventilation with or without resistance

SV - R / PSV / SV + R

Experimental group

Description:

Spontaneous ventilation without resistance / Pressure support ventilation / Spontaneous ventilation with resistance

Treatment:

Device: non-invasive ventilation with or without resistance

SV + R / PSV / SV - R

Experimental group

Description:

Spontaneous ventilation with resistance / Pressure support ventilation / Spontaneous ventilation without resistance

Treatment:

Device: non-invasive ventilation with or without resistance

SV + R / SV - R / PSV

Experimental group

Description:

Spontaneous ventilation with resistance / Spontaneous ventilation without resistance / Pressure support ventilation

Treatment:

Device: non-invasive ventilation with or without resistance

PSV / SV + R / SV - R

Experimental group

Description:

Pressure support ventilation / Spontaneous ventilation with resistance / Spontaneous ventilation without resistance

Treatment:

Device: non-invasive ventilation with or without resistance

PSV / SV - R / SV + R

Experimental group

Description:

Pressure support ventilation / Spontaneous ventilation without resistance / Spontaneous ventilation with resistance

Treatment:

Device: non-invasive ventilation with or without resistance