Surgery Benefits Takayasu Arteritis With Stenosis in the Descending Aorta

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Completed

Conditions: Takayasu Arteritis

Treatments: Procedure: open surgery or interventional treatment

Study type: Observational

Funder types: Other

Identifiers

NCT07149805

2022-PUMCH-A-191

BJZQ2024001 (Other Grant/Funding Number)

UBJ06532 (Other Grant/Funding Number)

Details and patient eligibility

About

The long-term prognosis and optimal management for Takayasu arteritis(TA) patients with severe stenosis of the descending thoracic and abdominal aorta remain undefined. We want to compare the clinical outcomes of surgical intervention and medical management.

Enrollment: 78 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. fulfilling the 1990 American College of Rheumatology criteria for the diagnosis of TA;
2. having at least one site with severe narrowing in the descending thoracic and abdominal aorta;
3. having symptoms caused by TA-related stenosis, such as uncontrolled hypertension, heart failure, renal ischemia, dizziness, visual disturbances, and claudication

Exclusion criteria

Patients with arterial stenosis due to other reasons (such as typical atherosclerosis, congenital coarctation of the aorta, and anatomical abnormality) were excluded

Trial design

78 participants in 2 patient groups

surgerical group

Description:

Patients who underwent surgical treatment

Treatment:

Procedure: open surgery or interventional treatment

conservative group

Description:

Patients who underwent conservative treatment