Surgery Versus No Surgery for Osteoarthritis (OA) of the Knee (MRC Knee)

University of Western Ontario, Canada

Status and phase: Completed; Phase 3

Conditions: Osteoarthritis of the Knee

Treatments: Other: Physical and medical therapy; Procedure: Arthroscopic surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT00562822

mrc123456

MCT-15227

Details and patient eligibility

About

The purpose of this study is to discover whether arthroscopic surgery is helpful in controlling the symptoms of osteoarthritis of the knee.

Full description

Although arthroscopic surgery has been widely used for osteoarthritis of the knee, scientific evidence to support its efficacy is lacking. This study will compare optimized physical and medical therapy alone with arthroscopic treatment in addition to optimized physical and medical therapy.

Enrollment: 188 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Idiopathic or secondary osteoarthritis of the knee with Grade II to IV radiographic severity as defined by the modified Kellgren and Lawrence classification

Exclusion criteria

• Patients with inflammatory or post-infectious arthritis
• Those who had undergone previous arthroscopic treatment for knee osteoarthritis
• Those with isolate Grade III to IV medical compartment osteoarthritis with greater than 5 degrees of varus deformity.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

188 participants in 2 patient groups

Arthroscopic Surgery

Active Comparator group

Description:

Arthroscopic surgery optimized with physical and medical therapy

Treatment:

Procedure: Arthroscopic surgery

Other: Physical and medical therapy

Physical and medical therapy

Active Comparator group

Description:

treatment with physical and medical therapy alone

Treatment:

Other: Physical and medical therapy