Surgical Evacuation Versus Methotrexate Injection in Treatment of Caesarean Scar Pregnancy [Clinical Trial ]

Minia University

Status and phase: Not yet enrolling; Phase 2

Conditions: Caesarean Scar Pregnancy

Treatments: Procedure: Surgical evacuation and methotrexate injection

Study type: Interventional

Funder types: Other

Identifiers

NCT07288307

CSP-MTX-01

Details and patient eligibility

About

The aim of the study is to compare the effectiveness and the complications of Ultrasound guided surgical evacuation versus using combined local and systemic methotrexate injection for management of caesarean scar pregnancy.

Enrollment: 42 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Gestation age Less than 12 weeks. Hemodynamically stable patient with un ruptured CSP. Non disturbed scar pregnancy . Acceptance of possible prolonged follow up, repeated HCG tests, the need for additional treatment doses and possible bleeding and subsequent hysterectomy.

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Exclusion criteria

• Patient refuse TOP. Gestation age More than 12 weeks . Hemodynamically unstable patient with ruptured CSP. Contraindication for methotrexate as hepatic disorders, renal disorders ,hypersensitivity to the drug and autoimmune diseases.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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42 participants in 2 patient groups

Ultrasound surgical evacuation

Experimental group

Treatment:

Procedure: Surgical evacuation and methotrexate injection

Local and systemic methotrexate injection

Active Comparator group

Treatment:

Procedure: Surgical evacuation and methotrexate injection