Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma

Mansoura University

Status

Completed

Conditions

Appendiceal Cancer

Treatments

Procedure: Hemicolectomy

Procedure: Partial colecctomy

Study type

Observational

Funder types

Other

Identifiers

NCT05452382

NCDBAppendix

Details and patient eligibility

About

A few studies investigated the predictors of overall survival in appendiceal adenocarcinoma. A SEER database analysis of 1404 patients with appendiceal adenocarcinoma found that older age, T4 tumors, N1-2 stage, poorly differentiated carcinoma, and distant metastasis were significantly predictive of poorer survival. Another small single-center study including 49 appendiceal cancer patients reported female gender and low-grade adenocarcinoma to be associated with increased overall survival. However, these previous analyses did not take into account some important prognosticators of survival such as patients' comorbidities and functional status, pathologic parameters such as lymphovascular invasion, and adjuvant systemic treatment. Therefore, we used the National Cancer Database (NCDB) to conduct a comprehensive analysis of the predictors of overall survival after surgical treatment of stage I-III appendiceal adenocarcinoma.

Enrollment

2,607 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

patients with non-metastatic appendiceal adenocarcinoma who underwent surgical resection

Exclusion criteria

Patients with other pathologic types of appendiceal cancer
Patients with clinical stage IV or unknown stage
Patients who did not undergo surgery, underwent local excision, or had unknown/non-specified surgery