Surveillance of Non-invasive Streptococcus Pneumoniae Infections in Belgium (STREPTO)

Sciensano

Status: Enrolling

Conditions: Sinusitis Bacterial; Otitis Media; Pneumonia

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT04447521

STREPTO1.2

Details and patient eligibility

About

The investigators will conduct a prospective observational study of non-invasive S. pneumoniae infections in Belgium and characterize serotype distributions to evaluate national vaccination programs.

Full description

The investigators will conduct a surveillance of non-invasive S. pneumoniae infections in Belgium (September 2020-May 2025). Monthly, 12 peripheral hospitals will send the first 15 unduplicated clinical S. pneumoniae samples (coming from patients diagnosed with pneumonia, otitits media or sinusitis) to the investigators. The investigators will determine the serotype and the antibiotic resistance profile of these clinical isolates. Whole genome sequencing will be performed on a subset of these isolates.

From May 2021, 13 extra participating centers have been added to the study.

Enrollment: 3,600 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients living in Belgium at the time of the study,
• from whom unduplicated S. pneumoniae isolates were collected in routine practices,
• from non-invasive upper (e.g.: pus/fluid from nasal sinus or from otitis media fluid) or lower respiratory tract (e.g. sputum bronchial or endotracheal aspirate, bronchoalveolar fluid (BAL),...) clinical samples,
• from patients diagnosed with pneumonia, sinusitis and otitis.

Exclusion criteria

• Patients for whom S. pneumoniae was simultaneously isolated from blood or another usually sterile specimen

Trial design