Survey and Reduction of Mortality in Peridialysis Uremic Patients Via Intervention of Risk Factors (SURVIVOR)

Naval Military Medical University (Second Military Medical University)

Status: Unknown

Conditions: End Stage Renal Disease on Dialysis

Treatments: Combination Product: intervention group

Study type: Interventional

Funder types: Other

Identifiers

NCT04088526

CZKIPLA-ESRD-001

Details and patient eligibility

About

In patients with non-dialysis-dependent end stage kidney disease (ESKD) the common transition of care to renal replacement therapy is dialysis. Each year over 70 000 Chinese transition from non-dialysis-dependent ESKD to dialysis. Whereas dialysis therapy is intended to be life-sustaining, ESKD patients have a 10-fold or higher risk of death compared with the general population. Mortality rates are even higher upon transition and in the first year, especially in the first 3 to 6 months following the transition to dialysis, yet it remains unknown which is the contributing cause of this high death rate. Hence, there is an urgent need to examine the emerging field of Transition of Care in ESKD. We suggest the term "peridialysis period" for this transition period for ESKD patients, so that the transition of care from non-dialysis-dependent ESKD to dialysis ESKD can be more pragmatically defined and studied. In the current study, we will investigate the mortality and its risk factors of ESKD patients during peridialysis period, and improve the survival rate and quality of life of peridialysis ESKD patients by intervening the risk factors.

Enrollment: 2,500 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who have been diagnosed with end stage kidney disease (eGFR<15ml/min/1.73m2) or newly started dialysis with 3 months at all hospitals in Yangzhou, China since January 1, 2016

Exclusion criteria

• Patients who have had a history of dialysis and have been transferred to Yangzhou during this period;
• patients who are transferred to a dialysis area outside Yangzhou City
• Patients who give up dialysis treatment
• patient whose renal function recover and stop dialysis treatment;
• Patient who receive kidney transplantation

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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2,500 participants in 1 patient group

intervention group

Experimental group

Description:

Through the effective intervention of risk factors for death in patients with dialysis, the effect of mortality of peri-dialysis patients was observed.

Treatment:

Combination Product: intervention group