Survival, Quality of Life and Resectability in Locally Advanced Pancreatic Cancer (SQUARE)

Umeå University

Status: Enrolling

Conditions: Chemotherapy Effect; Pancreas Adenocarcinoma; Quality of Life; Locally Advanced Pancreatic Adenocarcinoma; Surgery; Pancreas Disease; Borderline Resectable Pancreatic Adenocarcinoma; Pancreas Cancer; Pancreas Neoplasm

Study type: Observational

Funder types: Other

Identifiers

NCT05356039

UmU-square

Details and patient eligibility

About

This study aims to assess overall survival, quality of life and resection rates in locally advanced pancreatic cancer

Full description

This is a multicenter pragmatic prospective observational study including Nordic hospitals treating patients with borderline resectable and locally advanced pancreatic cancer. Eligibility will be assessed at regional multidisciplinary tumor boards. Patients with borderline resectable and locally advanced (non-endocrine) pancreatic cancer according to the National Comprehensive Cancer Network (NCCN) and the International Study Group of Pancreatic Surgery (ISGPS) are eligible for inclusion. The study is observational. Quality of life will be assessed in all study participants. The primary outcomes are exploration rates, resection rates and overall survival.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed or suspected invasive pancreatic primary tumor
• Tumor classified as borderline resectable or locally advanced disease according to NCCN guidelines

Exclusion criteria

• Suspected endocrine tumor
• Suspected non-pancreatic periampullary tumor
• Distant metastasis
• Age < 18 years
• Patient unable to understand verbal or written information interfering with informed consent or treatment
• Mental or organic disorder interfering with informed consent or treatments